Burleigh® offers unique Piezoelectric micromanipulator and microscope mounting solutions that combine unparalleled precision and control with ultimate stability essential for life science applications. Trusted by researchers worldwide, Burleigh® leverages our extensive expertise to deliver superior solutions with maximum performance and productivity for advanced research.

Simultaneous Pre- and Post-Synaptic Patch Clamp Recordings or any other multiple micromanipulator recording technique requires the combination of high-precision pipette placement and stability, ultra-low noise electronics and ergonomic comfort and convenience. The Dual Burleigh® PCS-6200 micromanipulator system is the ideal solution for these applications be they in slice or cell culture experimental arrangements.

The Burleigh® PCS-6200 utilizes three axes arranged in an X-Y-Z configuration for cell culture, or Approach-Y-Z for slice, and uses a combination of stepper motors and Piezoelectric positioning stages. The direct drive DC motors ensure smooth, accurate and fast macropositioning of the pipette. With a combination of one inch of motorized travel in each axis, along with easy-set memory positions, the Burleigh® PCS-6200 allows the investigator to approach each patch target quickly, accurately and with repeatability. The long travel motors, and intuitive fly-by-wire joystick control ensure that hunting for patch targets is fast, efficient and easy. The independent controls and power supplies ensure each manipulator is independent of the other, negating any accidental right/left control, or fine/coarse setting selection. Also, the independence of each manipulator allows the investigator to separate the two manipulators should their experimental needs change, without the additional cost of another set of controls. Furthermore, the included PC software with its simple and intuitive software interface, allows the investigator to not only control each manipulator remotely, but also have accurate positional readouts of both systems, in all three axes. This allows one to accurately measure cell diameters and correlate that data with cell capacitance measurements, ensuring a greater degree of control and experimental repeatability.

The Piezoelectric fine positioning stages allow the greatest degree of control and high-precision positioning for the final approach and patch. The Piezoelectric elements expand linearly with the voltage applied by the rotary potentiometers. This allows an ultra-smooth, highly controlled and intuitive connection between the electrophysiologist and the pipettes. Due to the linear expansion and unparalleled smooth control of the Piezoelectric fine controls, the investigator is confident of patching the smallest to the largest cell targets, without worrying about the jitteriness and drift often associated with completely stepper motor and hydraulic based systems. This smoothness and stability make the Burleigh® Dual PCS-6200 system ideal for Pre- and Post- recordings, such that the investigator is confident of each individual patch attainment and high stability.

Both the stepper motors and Piezoelectric stages are DC driven and independently grounded which abates any electrical noise from the micropositioners. Furthermore, the Burleigh® PCS-6200 is the only micromanipulator which incorporates a built in ground skeleton and grounding pin, ensuring noise-free operation and easy grounding. Finally, the Burleigh® PCS-6200 also incorporates a specialized electrostatic resistant coating, negating any build up of surface charge on the manipulator and eliminating the possibility of spike artefacts during these challenging experiments.

Sharp Electrode Recordings require an accurate, stable micromanipulator with smooth fine control of the electrode position. The Burleigh® PCS-5100 is the ideal manipulator for these applications.

The Burleigh® PCS-5100 utilizes three configurable axes arranged in an Approach-Y-Z configuration and uses a combination of manual micrometers and Piezoelectric positioning stages. The manual micrometers ensure smooth, convenient macropositioning of the pipette. With a combination of one inch of manual travel in each axis, along with easy-set rotary stage positions, the Burleigh® PCS-5100 allows the investigator to approach the patch target quickly, accurately and with repeatability. The long travel manual micrometers allow for intuitive pipette placement with finger tip controls over a wide range of motion, making hunting for cell targets fast, easy and efficient. The Piezoelectric fine positioning stages allow the greatest degree of control and high-precision positioning for the final approach and patch. The Piezoelectric elements expand linearly with the voltage applied by the rotary potentiometers. This allows an ultra-smooth, highly controlled and intuitive connection between the electrophysiologist and the sharp electrode. Due to the linear expansion and unparalleled smooth control of the Piezoelectric fine controls, the investigator is confident of fast-clean cell penetrations from the smallest to the largest cell targets, without worrying about the jitteriness and drift often associated with completely stepper motor and hydraulic based systems.

For two electrode voltage clamp, a combination of two Burleigh® PCS-5100; one right, one left, allow for a convenient, reliable and high-performing package ensuring experimental success at a great value.

Whole Cell Patch Clamp Recordings of Cultured Cells require the combination of high-precision pipette placement and stability, ultra-low noise electronics and ergonomic comfort and convenience. The Burleigh® PCS-6200-C is the ideal manipulator for these applications.

The Burleigh® PCS-6200-C utilizes three orthogonal axes arranged in an X-Y-Z configuration and uses a combination of stepper motors and Piezoelectric positioning stages. The direct drive DC motors ensure smooth, accurate and fast macropositioning of the pipette. With a combination of one inch of motorized travel in each axis, along with easy-set memory positions, the Burleigh® PCS-6200-C allows the investigator to approach the patch target quickly, accurately and with repeatability. The long travel motors, and intuitive fly-by-wire joystick control ensure that hunting for patch targets is fast, efficient and easy. Furthermore, the included PC software with its simple and intuitive software interface, allows the investigator to not only control the manipulator remotely, but also has, accurate positional readouts of all three axes. This allows one to accurately measure cell diameters and correlate that data with cell capacitance measurements, ensuring a greater degree of control and experimental repeatability. The Piezoelectric fine positioning stages allow the greatest degree of control and high-precision positioning for the final approach and patch. The Piezoelectric elements expand linearly with the voltage applied by the rotary potentiometers. This allows an ultra-smooth, highly controlled and intuitive connection between the electrophysiologist and the pipette. Due to the linear expansion and unparalleled smooth control of the Piezoelectric fine controls, the investigator is confident of patching the smallest to the largest cell targets, without worrying about the jitteriness and drift often associated with completely stepper motor and hydraulic based systems.

Both the stepper motors and Piezoelectric stages are DC driven and independently grounded which abates any electrical noise from the micropositioner. Furthermore, the Burleigh® PCS-6200-C is the only micromanipulator which incorporates a built in ground skeleton and grounding pin, ensuring noise-free operation and easy grounding. Finally, the Burleigh® PCS-6200-C also incorporates a specialized electrostatic resistant coating, negating any build up of surface charge on the manipulator and eliminating the possibility of spike artefacts in the recordings.

Single Channel Recordings require the combination of high-precision pipette placement and stability, as well as ultra-low noise electronics. The Burleigh® PCS-6200-C is the ideal manipulator for these applications.

The Burleigh® PCS-6200-C utilizes three orthogonal axes arranged in an XYZ configuration and uses a combination of stepper motors and Piezoelectric positioning stages. The direct drive DC motors ensure smooth, accurate and fast macropositioning of the pipette. With a combination of one inch of motorized travel in each axis, along with easy-set memory positions, the Burleigh® PCS-6200-C allows the investigator to approach the patch target quickly, accurately and with repeatability.

The Piezoelectric fine positioning stages allow the greatest degree of control and high-precision positioning for the final approach and patch. The Piezoelectric elements expand linearly with the voltage applied by the rotary potentiometers. This allows an ultra-smooth, highly controlled and intuitive connection between the electrophysiologist and the pipette. Due to the linear expansion and unparalleled smooth control of the Piezoelectric fine controls, the investigator is confident of patching even the smallest targets, without worrying about the jitteriness and drift often associated with completely stepper motor and hydraulic based systems.

Both the stepper motors and Piezoelectric stages are DC driven and independently grounded which abates any electrical noise from the micropositioner. Furthermore, the Burleigh® PCS-6200-C is the only micromanipulator which incorporates a built in ground skeleton and grounding pin, ensuring noise-free operation and easy grounding. Finally, the Burleigh® PCS-6200-C also incorporates a specialized electrostatic resistant coating, negating any build up of surface charge on the manipulator and eliminating the possibility of spike artefacts in the recordings.